7 by: Shannen Luchmanan
Student – Shannen Luchmanan
Name of Enzyme: Adenylate Cyclase
E.C # – 4.6.1.1
Adenylate cyclase also commonly known as Adenylyl cyclase is found mostly in the plasma membranes of mammals. It is an integral membrane-bound protein. Adenylate cyclase catalyzes the conversion of ATP to cAMP which is a secondary messenger and is used to activate a series of other enzymes. Adenylate cyclase requires Mg 2+ in order to bind with ATP. Adenylate cyclase can be stimulated by a wide variety of hormones including epinephrine, glucagon or can also be stimulated by Ca 2+. Its active site and regulatory sites are formed as a result of dimerization of the enzyme’s 2 catalytic domains.
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