42 by: Ethan Evans

Student – Ethan Evans

Enzyme & EC # – Lipoprotein Lipase; 3.1.1.34

Where is Lipoprotein Lipase Located? Lipoprotein Lipase is an enzyme found in adipose tissue, muscle tissue, and heart tissue. It can be located anchored onto the walls of capillaries on the vascular endothelial surface. Lipoprotein Lipase is bound to the walls of capillaries by glycosylphosphatidylinositol HDL-binding protein 1.

What is its function within the human body? This enzyme is important as it catalyzes the hydrolysis of triglycerol present in VLDL and chylomicron particles. This catalyzation of these molecules is activated by apolipoprotein-CII (apoCII). Fortunately for Lipoprotein Lipase, apoCII is found on VLDL. The end result of this reaction is the production of fatty acids, and monoacylglycerol.

Facts: Lipoprotein Lipase is a homodimer that is produced in heart muscle and fat tissue, and was first discovered in 1943 by Paul Hahn.

References:
Lipoprotein Lipase – an overview | ScienceDirect Topics. wwwsciencedirectcom. https://www.sciencedirect.com/topics/medicine-and-dentistry/lipoprotein-lipase.
Pirahanchi Y, Anoruo M, Sharma S. 2021. Biochemistry, Lipoprotein Lipase. PubMed. https://www.ncbi.nlm.nih.gov/books/NBK537040/.